GRANULOMATOSIS WITH POLYANGIITIS IN A PATIENT TREATED WITH DABRAFENIB AND TRAMETINIB FOR BRAF V600E POSITIVE LUNG ADENOCARCINOMA

Granulomatosis with polyangiitis in a patient treated with dabrafenib and trametinib for BRAF V600E positive lung adenocarcinoma

Abstract Background Dabrafenib Baby Food and trametinib combination therapy is approved for the treatment of patients with BRAF V600E positive tumors including melanoma and lung cancer.The effect of BRAF and MEK inhibitors on the immune system is not fully understood although a number of case reports indicate autoimmune side effects related to the

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Heat and flow analysis of a bioconvective second-grade nanofluid with multiple slip effect over a stretching porous cylinder

Fluid motions in cylindrical domains have many applications in the vital areas like as chemical processes, food industry, bioengineering, oil exploitation, etc.The aims of current research is to investigate the Darcy-Forchheimer bio-convective flow of a Second-grade nanofluid over a porous stretching cylinder.The flow model incorporates with severa

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Usefulness of Gamma Glutamyl Transferase as Reliable Biological Marker in Objective Corroboration of Relapse in Alcohol Dependent Patients

Introduction: The development of reliable diagnostic tool for assessing alcoholism is an utmost necessity in treating and preventing damage due to alcoholism to both individual and armed forces as alcoholism represents a serious health issue with major socioeconomic consequences.Aim: To observe, gamma glutamyl transferase (GGT) can serve the practi

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Nitrogen remobilization in shoots of Paris polyphylla is altered by gibberellic acid application during senescence

Nitrogen remobilization during senescence has been studied in perennial herb Paris polyphylla.We analyzed changes in N content, amino acids, N-remobilization enzymes and effects of gibberellic acid (GA) during natural senescence.There was a gradual decrease in the contents of N, chlorophyll and soluble proteins and activities of glutamine synthetas

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